Dengue remains a pressing global health challenge, especially in tropical and subtropical regions like India, Southeast Asia, and South America. With rising caseloads and overlapping symptoms with Zika, Chikungunya and even COVID-19, early and reliable diagnosis is critical.
Among various diagnostic targets, the Dengue Non-Structural Protein 1 (NS1) stands out as a gold-standard biomarker — detectable within 1–2 days of symptom onset, making it ideal for early-stage screening and outbreak control.
At Denovo Biolabs, we manufacture and supply high-purity, assay-ready recombinant Dengue NS1 antigen and LFA-validated antibody pairs, enabling diagnostic developers and CROs to build faster, more accurate assays.
Why Target NS1 in Dengue Diagnosis?
NS1 is a secreted glycoprotein found in the bloodstream of infected individuals during the acute phase of infection often before IgM or IgG antibodies become detectable.
Using NS1 as a diagnostic target allows:
- Early detection (Day 1–5 of infection)
- Serotype-independent detection (works across DENV 1–4)
- Fewer false positives compared to antibody-only tests
- Compatibility with both ELISA and LFA formats
This makes NS1 an ideal choice for field testing, mass screening, and clinical diagnostics — especially when paired with validated recombinant reagents.
Recombinant NS1 vs. Native NS1
Denovo’s recombinant Dengue NS1 is available in both E. coli and mammalian expression formats, QC-verified for purity and binding activity, and supplied ready for direct use in immunoassays.
Denovo Biolabs’ NS1 Product Line
We support diagnostics manufacturers, CROs, and academic labs with the following:
Recombinant Dengue NS1 Antigen
- ≥ 95% purity (SDS-PAGE/HPLC validated)
- Liquid or lyophilized formats
- Compatible with LFA, ELISA, Western blot and R&D workflows
- Tag-free or custom-tagged formats on request
LFA-Validated Antibody Pairs (for NS1)
- Monoclonal capture & detection antibodies
- Optimized for strip development and plate coating
- Minimal cross-reactivity with other flaviviruses (Zika, Yellow Fever)
- Scalable production with performance data available
Applications of Denovo’s NS1 Antigens & Antibodies
- Lateral Flow Assays (LFA):
Rapid, point-of-care detection for clinics and outbreak zones - ELISA Kits:
Quantitative or qualitative analysis in clinical labs - Multiplex Panels:
Combine NS1 with DENV/Zika/CHIKV markers for broader surveillance - Antibody Screening & Vaccine R&D:
Research use in serology, antibody validation, or epitope mapping
The Make-in-India Advantage
We are committed to enabling self-reliance in biotech by producing high-quality diagnostic reagents in India, validated for local matrices, and backed with technical support, batch traceability, and shorter lead times.
Here is why diagnostic developers trust Denovo Biolabs:
- ISO-grade manufacturing processes
- Custom protein development & bulk scale options
- Local QC, faster turnaround and complete documentation support
- Technical assistance for conjugation, coating and assay development
Ready to build better Dengue kits?
If you are a diagnostics manufacturer, CRO, or research lab looking to develop or scale Dengue NS1-based tests, we can help you get there faster with reagents that perform where it matters most: in the real world.